A Simple and Effective Protocol for the Pechmann Reaction to Obtain 4-Methylcoumarin Derivatives Using a High-Speed Mixer Ball Mill Process by Silvia J. Becerra-Anaya Diego R. Merchán Arenas & Vladimir V. Kouznetsov

Author:Silvia J. Becerra-Anaya, Diego R. Merchán Arenas & Vladimir V. Kouznetsov
Format: pdf
Tags: We hereby report a simple and efficient method for the preparation of 4-methylcoumarins series, including Coumarin 120 (7-amino-4-methylcoumarin) from phenols (or naphthols) and ethyl acetoacetate in the presence of 3 mol% InCl3. Coumarins were obtained in good yields (52–92%) through Pechmann condensation, under a rapid and environmentally friendly protocol using a high-speed ball mill mixer at room temperature, with short reaction times, under solvent-free conditions., Pechmann reaction; 4-methylcoumarins; 4-methyl-2H-chromen-2-ones; solvent-free condensation; mechanochemical activation; ball milling; high-speed mixer ball mill process; InCl3-catalysis


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